Adefovir

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Adefovir

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Cat No: 18650

Adefovir is an active metabolite of the antiviral nucleoside analog adefovir dipivoxil (Item No. 28373).{56174} Adefovir is formed from adefovir dipivoxil by gastrointestinal carboxylesterase 2 (CES2).{56175} It inhibits cytopathogenicity induced by h...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

P-[[2-(6-amino-9H-purin-9-yl)ethoxy]methyl]-phosphonic acid

Correlated keywords:

hepatitis B reverse transcriptase acyclic nucleoside phosphonate HIV herpes GS-393 GS0393 GS393 hepsera HSV-1 HSV-2 VZV CMV EBV HHV-6 HHV-7 HHV8 HSV1 HSV2 HHV6 HHV7 HHV-8 HBV HIV-1 HIV-2 SIV FIV HIV1 HIV2

Product Overview:
Adefovir is an active metabolite of the antiviral nucleoside analog adefovir dipivoxil (Item No. 28373).{56174} Adefovir is formed from adefovir dipivoxil by gastrointestinal carboxylesterase 2 (CES2).{56175} It inhibits cytopathogenicity induced by herpes simplex virus 1 (HSV-1) and HSV-2 (EC50 = 7 µg/ml for both in E6SM cells), HIV-1 and HIV-2 (EC50s = 1.8 and 2.5 µg/ml, respectively, in CEM cells), and varicella zoster virus (VZV; EC50 = 10 µg/ml in human embryonic lung fibroblasts).{56176} Adefovir (50 mg/kg, p.o.) reduces increases in lymph node viral DNA and serum IgG levels in a mouse model of AIDS induced by infection with the retroviral complex LP-BM5.{56177} It also inhibits tumor growth induced by Moloney sarcoma virus (MSV) infection in mice at the same dose.{56178}

Size	10 mg
Shipping	dry ice
CAS Number	106941-25-7
Molecular Formula	C₈H₁₂N₅O₄P
SMILES	NC1=C2C(N(CCOCP(O)(O)=O)C=N2)=NC=N1
Molecular Weight	273,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.