4E1RCat

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4E1RCat

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Cat No: 18399

Biochemicals - Small Molecule Inhibitors

4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.{31602} It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 valu...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-?[2,?3-?dihydro-?3-?[[5-?(4-?nitrophenyl)?-??2-?furanyl]?methylene]?-??2-?oxo-?5-?phenyl-?1H-??pyrrol-?1-?yl]?-?benzoic acid

Correlated keywords:

4E1R-Cat 4-E1RCat 4-E1R-Cat 4E1-RCat eIF4E:eIF4G eIF4E:4E-BP1 interaction eIF4E/eIF4G eIF4E/4E-BP1 eIF4E eIF4G 4E-BP1 4EBP1 eIF4F complex cap-dependent translation

Product Overview:
4E1RCat is an inhibitor of the eIF4F translation initiation complex that blocks eIF4E:eIF4G and eIF4E:4E-BP1 interactions.{31602} It has been shown to prevent the assembly of the eIF4F complex and to inhibit cap-dependent translation with an IC50 value of ~4 μM.{31602} 4E1RCat was shown to reverse tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage.{31602}

Size	1 mg
Shipping	dry ice
CAS Number	328998-25-0
Molecular Formula	C₂₈H₁₈N₂O₆
SMILES	O=C1/C(C=C(C2=CC=CC=C2)N1C3=CC=C(C(O)=O)C=C3)=C\C4=CC=C(C5=CC=C([N+]([O-])=O)C=C5)O4
Molecular Weight	478,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2932.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.