Eliprodil

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Eliprodil

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Cat No: 18398

Biochemicals - Ion Channel Modulation

N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

?-?(4-?chlorophenyl)?-?4-?[(4-?fluorophenyl)?methyl]?-1-?piperidineethanol

Correlated keywords:

126613-29-4 127293-58-7 136634-88-3 SL820715 NR2B-NDMA neuronal calcium channel current Ca2+ NR-2B N-methyl-D-aspartate CA-1

Product Overview:
N-Methyl-D-aspartate (NMDA) receptors are calcium permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. Eliprodil is a non-competitive NMDA receptor antagonist that inhibits neuronal calcium channel currents.{31071} It is selective for NR2B subunit-containing receptors (IC50 = 1 µM), displaying greater than 100-fold selectivity for NR2B over NR2A and NR2C subunits.{31074,31072} Eliprodil also avidly binds σ1 and σ2 sites (Kis = 0.013 and 0.63 µM, respectively).{31074} It is effective in vivo, blocking ischemia-induced neurodegeneration in the CA1 region of the hippocampus of gerbils subjected to bilateral carotid artery occlusion.{31071} Eliprodil can also have proarrhythmic actions in hearts under normal conditions.{31073}

Size	1 mg
Shipping	dry ice
CAS Number	119431-25-3
Molecular Formula	C₂₀H₂₃ClFNO
SMILES	FC1=CC=C(CC2CCN(CC(O)C3=CC=C(Cl)C=C3)CC2)C=C1
Molecular Weight	347,9
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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ISO Guide 34:2009

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