Histone H2A (Xenopus, recombinant)
Histone H2A (Xenopus, recombinant)
Histone H2A is a core histone that forms a dimer with histone H2B.{46631} Two histone H2A/H2B dimers form an octameric...
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From €66.00 €56.10
MLN2238 is an inhibitor of the ?5 subunit of the 20S proteasome (IC50 = 3.4 nM in a cell-free assay) and an active metabolite of MLN9708 (Item No. 18386).{31628,31627} It is formed from MLN9708 via hydrolysis in plasma.{31628} MLN2238 is selective for the chymotrypsin-like ?5 subunit over the caspase-like ?1 and trypsin-like ?2 subunits (IC50s = 31 and 3,500 nM, respectively). It also binds caseinolytic protease P (Kd = 5,700 nM) and prevents hemolysis of isolated ovine erythrocytes induced by methicillin-resistant S. aureus (MRSA; EC50 = 3,600 nM).{58924} MLN2238 inhibits the proliferation of A375 and H460 lung and HCT116 and HT-29 colon cancer cells (IC50s = 20, 58, 19, and 52 nM, respectively) as well as osteoclastogenesis in peripheral blood mononuclear cells (PBMCs) isolated from patients with multiple myeloma (IC50 = 4.8 nM).{31628,31627} It reduces tumor growth in a CWR22 prostate cancer mouse xenograft model when administered at a dose of 14 mg/kg. Formulations containing MLN2238 have been used in the treatment of multiple myeloma.
Territorial Availability: Available through Bertin Technologies only in France
| Size | 1 mg, 10 mg, 5 mg, 50 mg |
|---|---|
| Shipping | dry ice |
| CAS number | 1072833-77-2 |
| Molecular formula | C14H19BCl2N2O4 |
| Smiles | ClC1=C(C(NCC(N[C@H](B(O)O)CC(C)C)=O)=O)C=C(Cl)C=C1 |
| Molecular weight | 361 |
| Custom code | 2922.19 |
| Formulation | A crystalline solid |
| Purity | ≥95% |
| UNSPSC code | 12352100 |
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