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(±)-Nicotine-d3

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    (±)-Nicotine-d<sub>3</sub>
  • (±)-Nicotine-d<sub>3</sub>
Cat No: 18256
Biochemicals - Isotopically Labeled Standards
Cayman

(±)-Nicotine-d3 is intended for use as an internal standard for the quantification of (±)-nicotine (Item No. 16535) by GC- or LC-mass spectrometry. (±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an ago...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 3-[1-(methyl-d3)-2-pyrrolidinyl]-pyridine
Correlated keywords:
  • deuterated deuterium GC-MS GC/MS gase chromatography masse spectrometry LC-MS LC/MS liquid isotope alkaloid tobacco plant neuronal nicotinic acetylcholine nAChR a3B4 a4B2 n-AChR ACh GCMS LCMS
Product Overview:
(±)-Nicotine-d3 is intended for use as an internal standard for the quantification of (±)-nicotine (Item No. 16535) by GC- or LC-mass spectrometry. (±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs; Kis = 481 and 11.1 nM for α3β4 and α4β2 subtypes, respectively) and possesses addictive and teratogenic properties.{18814} (−)-(S)-Nicotine is significantly more active at binding nAChRs compared to the (+)-(R) antipode, thus nicotine is typically synthesized as (−)-(S)-nicotine with only 0.2-1% of the (+)-(R) isomer present.{26727}
Size 5 mg
Shipping dry ice
CAS Number 69980-24-1
Molecular Formula C10H11D3N2
SMILES [2H]C([2H])([2H])N1CCCC1C2=CC=CN=C2
Molecular Weight 165,3
Formulation A solution in ethanol
Purity ≥99% deuterated forms (d1-d3)
Custom Code 3822.19
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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