p-nitro-Cyclic Pifithrin-?

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Cat No: 17848

Biochemicals - Small Molecule Inhibitors

Pifithrin-α (PFT-α; Item No. 13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.{17259} Cyclic PFT-α (Item No. 14748) is a stable analog of PFT-α.{23585} p-nitro-Cyclic PFT-α is a cell-permeable form of c...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5,6,7,8-tetrahydro-2-(4-nitrophenyl)-imidazo[2,1-b]benzothiazole

Correlated keywords:

511296-89-2 biochemical inhibitor apoptosis cancer intracellular signaling neuroscience gene regulation signal transduction inhibit para-nitro cell-permeable PFT?

Product Overview:
Pifithrin-α (PFT-α; Item No. 13326) is an inactivator of p53 that blocks p53-dependent transcriptional activation and apoptosis.{17259} Cyclic PFT-α (Item No. 14748) is a stable analog of PFT-α.{23585} p-nitro-Cyclic PFT-α is a cell-permeable form of cyclic PFT-α.{23578} It is one order of magnitude more active that PFT-α in protecting cortical neurons exposed to etoposide (ED50 = 30 nM).{23578} p-nitro-Cyclic PFT-α acts in a p53-dependent manner but does not block phosphorylation of p53 on Ser15 in response to etoposide treatment, although it prevents p53 posttranscriptional activity.{23578} Although it is more stable in solution than the parent compound, this derivative is not active in vivo.{23578}

Size	1 mg
Shipping	dry ice
CAS Number	60477-38-5
Molecular Formula	C₁₅H₁₃N₃O₂S
SMILES	O=[N+](C(C=C1)=CC=C1C2=CN(C(S3)=N2)C4=C3CCCC4)[O-]
Molecular Weight	299,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

Technical File

MSDS

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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