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Calcitriol

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    Calcitriol
  • Calcitriol
Cat No: 71820
Biochemicals - Natural Products
Cayman
€90.00
Price is excluding VAT and does not include packaging neither shipping

Calcitriol is synthesized from 7-dehydro cholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin.{10412} Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy vitamin D3, the pri...

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This product can only be bought through Cayman Chemical. Please contact us.

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 9,10-secocholesta-5Z,7E,10(19)-triene-1α,3β,25-triol
Correlated keywords:
  • osteoblasts calcium absorption homeostasis regulators calcium absorption homeostasis regulators 1,25-dihydroxy-vitamin 1a,25-dihydroxy-vitamin endocrinology agonist vitamin D receptor osteoblasts calcium absorption homeostasis regulators calcium absorption homeostasis regulators 1,25-dihydroxy-vitamin 1a,25-dihydroxy-vitamin endocrinology agonist vitamin D receptor
Product Overview:
Calcitriol is synthesized from 7-dehydro cholesterol in humans via a non-enzymatic photochemical reaction with 290-310 nm UV light in the skin.{10412} Hydroxylation of the resulting cholecalciferol in the liver produces 25-hydroxy vitamin D3, the principal circulating form of vitamin D. A second, tightly regulated hydroxylation in the kidney produces calcitriol. Plasma calcitriol levels range from 10-70 pg/ml and are influenced by numerous dietary and hormonal factors.{10312} The main physiologic effects of calcitriol are to increase the absorption of calcium at the level of the intestinal epithelium, and to increase the mineralization of bone via the direct stimulation of osteoblasts.{10411}
Size 1 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 730 days
CAS Number 32222-06-3
Molecular Formula C27H44O3
SMILES O[C@@H](C[C@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@@]3([C@H](C)CCCC(C)(O)C)[H])([H])[C@]3(C)CCC\2
Molecular Weight 416,6
Formulation A crystalline solid
Purity ≥97%
Custom Code 2907.29
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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