Sephin1

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Sephin1

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Cat No: 17757

Biochemicals - Small Molecule Inhibitors

Protein phosphatase 1C (PP1c) dephosphorylates the eukaryotic translation initiation factor 2α subunit (eIF2α) to turn off the unfolded protein response in the endoplasmic reticulum (ER). PP1c removes phosphates on eIF2α under the direction of one of t...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[(2-chlorophenyl)methylene]-hydrazinecarboximidamide

Correlated keywords:

32597-86-7 951441-04-6 951345-60-1 proteostasis inhibitor ER stress Protein phosphatase 1C PPP1R15A protein phosphatase 1 regulatory subunit eukaryotic translation initiation factor 2? subunit eIF2? phosphorylation protein misfolding amyotrophic lateral sclerosis ALS Charcot-Marie-Tooth neuropathy neuroscience biochemical inhibit signal transduction sephin-1 benzaldehyde o-chloro amidinohydrazone NSC65390

Product Overview:
Protein phosphatase 1C (PP1c) dephosphorylates the eukaryotic translation initiation factor 2α subunit (eIF2α) to turn off the unfolded protein response in the endoplasmic reticulum (ER). PP1c removes phosphates on eIF2α under the direction of one of two accessory subunits termed protein phosphatase 1 regulatory subunit 15A and 15B (PPP1R15A and PPP1R15B). Whereas PPP1R15B is constitutively expressed, PPP1R15A is induced by protein-misfolding stress. Sephin1 is a selective inhibitor of the stress-induced PPP1R15A that does not affect the constitutive PPP1R15B.{28743} At 50 µM, it has been shown to prolong eIF2α phosphorylation after ER stress, delaying translation which protects cells from misfolded protein-induced cytotoxicity.{28743} At 1-5 mg/kg, sephin1 has been shown to prevent defects resulting from protein misfolding in a mutant SOD1 mouse model of fast-progressing amyotrophic lateral sclerosis as well as a mouse model of Charcot-Marie-Tooth neuropathy.{28743}

Size	500 µg
Shipping	dry ice
CAS Number	13098-73-2
Molecular Formula	C₈H₉ClN₄
SMILES	ClC1=C(/C=N/NC(N)=N)C=CC=C1
Molecular Weight	196,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.