Confirm delete?

Bertin Bioreagent
logo
All categories
Contact Us
You are here :

AH 7614

  • Zoom
    AH 7614
  • AH 7614
Cat No: 17713
Biochemicals - Receptor Pharmacology
Cayman

Free fatty acid receptor 4 (FFAR4/GPR120) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.{27421,22326} ω-3 Fatty acids, such as docosahexaenoic acid...

More

This product can only be bought through Cayman Chemical. Please contact us.

Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 4-methyl-N-9H-xanthen-9-yl-benzenesulfonamide
Correlated keywords:
  • free fatty acid receptor 4 antagonist FFAR4 FFA4 GPR120 inflammation long chain biochemical lipid mediator signal transduction FFAR-4 FFA-4 GPR-120 G protein-coupled AH7614 NSC31171
Product Overview:
Free fatty acid receptor 4 (FFAR4/GPR120) is a G protein-coupled receptor expressed in intestine, adipocytes, and pro-inflammatory macrophages that is activated by long chain free fatty acids.{27421,22326} ω-3 Fatty acids, such as docosahexaenoic acid (Item No. 90310) and eicosapentaenoic acid (Item No. 90110), initiate FFAR4 signaling, resulting in inhibition of toll-like receptor and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.{22326} AH 7614 is a selective FFAR4 antagonist (IC50s = 0.079 and 25 µM for human FFAR4 and FFAR1 receptors, respectively).{28870} In U2OS osteosarcoma cells expressing the FFAR4 receptor, it has been shown to inhibit intracellular calcium accumulation induced by either linoleic acid or an FFAR4 agonist.{28870}
Size 1 mg
Shipping dry ice
CAS Number 03/06/6326 00:00
Molecular Formula C20H17NO3S
SMILES CC1=CC=C(S(NC2C(C=CC=C3)=C3OC4=C2C=CC=C4)(=O)=O)C=C1
Molecular Weight 351,4
Formulation A crystalline solid
Purity ≥98%
Custom Code 2932.99
UNSPSC code 12352100

Click here to ask for your quote and get 15% off Cayman's products.

 

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

/ We also advise you

Cross selling for this product : AH 7614 There are 10 products.

Search