cis-Flupenthixol (hydrochloride)

Biochemicals - Receptor Pharmacology

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Cat No: 17634

Biochemicals - Receptor Pharmacology

cis-Flupenthixol is a typical antipsychotic, a dopamine D2 receptor antagonist (Ki = 0.38 nM), and an inverse agonist at the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 7 nM).{26444} In vivo, cis-flupenthixol (0.5 mg/kg, i.p.) reduces cocaine-induc...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[3-[(3Z)-2-(trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol, dihydrochloride

Correlated keywords:

53772-82-0 2413-38-9 51529-02-3 Thioxanthene cis-(Z)-Flupenthixol ?- flupenthixol anti-psychotic 5HT 5HT2A 2A

Product Overview:
cis-Flupenthixol is a typical antipsychotic, a dopamine D2 receptor antagonist (Ki = 0.38 nM), and an inverse agonist at the serotonin (5-HT) receptor subtype 5-HT2A (Ki = 7 nM).{26444} In vivo, cis-flupenthixol (0.5 mg/kg, i.p.) reduces cocaine-induced locomotor activity and prevents development of conditioned place preferences for the immediate effects of intravenously administered cocaine without affecting development of conditioned place aversions in rats.{42313} cis-Flupenthixol also inhibits acid sphingomyelinase activity by 81.8% when used at a concentration of 10 mM.{26583}

Size	1 mg
Shipping	dry ice
CAS Number	51529-01-2
Molecular Formula	C₂₃H₂₅F₃N₂OS • 2HCl
SMILES	OCCN(CC1)CCN1CC/C=C2C3=C(C=CC(C(F)(F)F)=C3)SC4=CC=CC=C4\2.Cl.Cl
Molecular Weight	507,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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