COX-1 (human, recombinant)

Proteins - Enzymes

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Cat No: 17616

Proteins - Enzymes

COX-1 and -2, also called prostaglandin endoperoxide H synthases-1 and -2, are key regulatory enzymes in the prostaglandin biosynthetic pathway. COX enzymes catalyze the committed step in the conversion of arachidonic acid (Item No. 90010) to prostag...

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Territorial Availability: Available through Bertin Technologies only in France

Correlated keywords:

COX1 PGHS1 PHS1 protein eicosanoid enzyme activity lipid pain prostaglandin recombinant cyclooxygenase inflammation NSAID P23219 P-23219 H Synthase PGH PHS-1

Product Overview:
COX-1 and -2, also called prostaglandin endoperoxide H synthases-1 and -2, are key regulatory enzymes in the prostaglandin biosynthetic pathway. COX enzymes catalyze the committed step in the conversion of arachidonic acid (Item No. 90010) to prostaglandin H2 (Item No. 17020). These enzymes are the major targets for NSAIDs that are used to reduce pain, inflammation, and fever.{8931}

Size	5 Kunits
Shipping	dry ice
Host	Insect cells
Formulation	80 mM Tris, pH 8.0, with 0.01% polysorbate 20, 300 µM DDC, and 10% glycerol
Purity	≥85% estimated by SDS-PAGE
Custom Code	3504.00
UNSPSC code	12352204

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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