Dequalinium (chloride)

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Cat No: 17557

Dequalinium is a quaternary ammonium cation with diverse biological activities.{43478,43479,43480} It has antifungal activity against C. albicans, C. glabrata, and C. krusei (MICs = 0.5-2, 64-256, and 128 μg/ml, respectively), antitrichomonal activity...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1,1'-(1,10-decanediyl)bis[4-amino-2-methyl-quinolinium, dichloride

Correlated keywords:

856599-47-8 1257422-27-7 6707-58-0 Decamine Decatylen Dekadin Dekamiln Dekamin Dequacets Dequadin Dequafungen Dequavet Efisol Eriosept Evazol Fluomycin N Grocreme Ivazil LDN 0096422 LDN0096422 Labosept Optipect Oralgol Phylletten Polycidine Rumilet Sanoral Sentril Sorot NSC166454 Sk-ca W-176 Candida Trichomonas anti-bacterial -biotic -fungal trichomonal BADQ BAQD-10 BADQ10 BAQD10

Product Overview:
Dequalinium is a quaternary ammonium cation with diverse biological activities.{43478,43479,43480} It has antifungal activity against C. albicans, C. glabrata, and C. krusei (MICs = 0.5-2, 64-256, and 128 μg/ml, respectively), antitrichomonal activity against T. vaginalis (MICs = 28.8-230.4 µg/ml), and antibacterial activity against a panel of aerobic and facultative anaerobic bacteria (MICs = 0.25-256 µg/ml).{43478} Dequalinium inhibits apamin binding to, and net potassium loss mediated by, SKCa channels in guinea pig hepatocytes stimulated by angiotensin II (Item No. 17150).{43479} In vivo, dequalinium (1-10 mg/kg) inhibits primary and recurrent tumor growth in a W163 rat colon carcinoma isograft model.{43480}

Size	250 mg
Shipping	dry ice
CAS Number	522-51-0
Molecular Formula	C₃₀H₄₀N₄ • 2Cl
SMILES	CC1=[N+](CCCCCCCCCC[N+]2=C(C=CC=C3)C3=C(N)C=C2C)C4=CC=CC=C4C(N)=C1.[Cl-].[Cl-]
Molecular Weight	527,6
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.39
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.