Cytosporone B

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Cytosporone B

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Cat No: 17501

Biochemicals - Receptor Pharmacology

Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).{28698} Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.{28698} Signaling throu...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester

Correlated keywords:

biochemical natural product agonist signal transduction nuclear receptor gene regulation antibiotic atherosclerosis cancer apoptosis mitochondrial biology Nur77 Nur 77 CsnB

Product Overview:
Cytosporone B is a naturally occurring agonist for the nuclear receptor Nur77 (IC50 = 0.278 nM).{28698} Activation of Nur77 with cytosporone B induces the expression of Nur77-dependent genes, including the gene for Nur77 itself.{28698} Signaling through Nur77 induces apoptosis in cancer cells and retards xenograft tumor growth.{28698} It also induces genes related to gluconeogenesis and decreases atherosclerosis progression in mice fed a high fat and high cholesterol diet.{28698,28695} Cytosporone B is brain penetrant and aggravates early brain injury in rats when given (13 mg/kg intraperitoneally) after experimentally-induced subarachnoid hemorrhage.{28694} Cytosporone B also has antibacterial properties.{28693,28696}

Size	1 mg
Shipping	dry ice
CAS Number	321661-62-5
Molecular Formula	C₁₈H₂₆O₅
SMILES	OC1=CC(CC(OCC)=O)=C(C(CCCCCCC)=O)C(O)=C1
Molecular Weight	322,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.