BAZ2-ICR

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BAZ2-ICR

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Cat No: 17448

Biochemicals - Small Molecule Inhibitors

BAZ2A/B are bromodomain-containing proteins whose biological function, while not yet confirmed, is believed to function similarly to ACF1, the Drosophila BAZ2B ortholog. ACF complexes play roles in establishing regular nucleosome spacing during chromat...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-?[4-?(1-?methyl-?1H-?pyrazol-?4-?yl)?-?1-?[2-?(1-?methyl-?1H-?pyrazol-?4-?yl)?ethyl]?-?1H-?imidazol-?5-?yl]?-benzonitrile

Correlated keywords:

inhibitor BAZ2A BAZ2B bromodomain epigenetic reader chromatin gene regulation biochemical research inhibit BAZ2ICR Structural genomic consortium SGC

Product Overview:
BAZ2A/B are bromodomain-containing proteins whose biological function, while not yet confirmed, is believed to function similarly to ACF1, the Drosophila BAZ2B ortholog. ACF complexes play roles in establishing regular nucleosome spacing during chromatin assembly and influencing different remodeling outcomes at target loci.{21672,21674} A rare allele of BAZ2B has been identified to be a predictor of Sudden Cardiac Death.{21319} BAZ2-ICR is a small molecule inhibitor of BAZ2A (Kd = 109 nM; IC50 = 130 nM) and BAZ2B (Kd = 170 nM; IC50 = 180 nM) bromodomains.{28479} It demonstrates 15-fold selectivity for binding BAZ2A/B over CECR2 and >100-fold selectivity over all other bromodomains.{28479} BAZ2-ICR has been shown to displace BAZ2 bromodomains in living cells by demonstrating accelerated FRAP recovery at 1 µM in the BAZ2A FRAP assay.{28479} See the Structural Genomics Consortium (SGC) website for more information.

Size	1 mg
Shipping	dry ice
CAS Number	1665195-94-7
Molecular Formula	C₂₀H₁₉N₇
SMILES	CN1C=C(CCN2C=NC(C3=CN(C)N=C3)=C2C4=CC=C(C#N)C=C4)C=N1
Molecular Weight	357,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2837.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.