Prion Protein Monoclonal Antibody - 12F10

Antibodies - Monoclonal Antibodies

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Cat No: A03221

Antibodies - Monoclonal Antibodies

Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its huma...

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                        Territorial Availability: Available worldwide directly through Bertin or your local distributor
                    

Synonyms:

Prion Protein Monoclonal Antibody - 12F10

Correlated keywords:

proteins

diseases

bovine

spongiform

encephalopathy

scrapie

Creutzfeldt-jakob

neurodegeneration

antibodies

antisera

antiserum

neurochemistry

neuroscience

spi-bio

spibio

A03200

Product Overview:
Prion Protein (PrP) and namely its abnormal isoform, partially resistant to proteinase K (PrPres), is the only specific molecular marker of the Transmissible Spongiform Encephalopathies (TSEs) such as Bovine Spongiform Encephalopathie (BSE) or its human form, the New Variant of Creutzfeld-Jakob disease.
This antibody recognises the protein sequence within amino acids 142-160 (human numbering).

Size	200 µg
Shipping	Dry Ice
Host	Mouse
Antigen	This anti-Prion Protein Monoclonal Antibody was raised against a human recombinant protein.
Clone	12F10
Isotype	IgG2a
Application(s)	Reconstitute the content of the vial in 1 mL of water. For immunohistochemistry, the optimal working dilution must be determined empirically (currently between 0.1 and 1 µg/mL). For western blot analysis of PrPc, dilute the antibody to a final concentration of 1 µg/mL.
Specificity	PrPc (+/-) Hamster, (+/-) Mouse, (+) Bovine, (+) Ovine, (+) Human
Application Media	Reconstitute the content of the vial in 1 mL of water.
Formulation	lyophilized IgG with BSA
Custom Code	3822000000
UNSPSC code	12352203

Krasemann S. et al. Generation of monoclonal antibodies against prion proteins with an unconventional nucleic acid-based immunization strategy. Journal of Biotechnology 73, 119-129 (1999).

Krasemann S. et al. Induction of antibodies against human prion proteins (PrP) by DNA-mediated immunization of PrP 0/0 mice. Journal of Immunological Methods 199, 109-118 (1996).

Krasemann S. et al. Generation of monoclonal antibody against Human prion proteins in PrP 0/0 Mice.

Molecular Medecine, 2, 725-731 (1996).

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