IMD 0354

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IMD 0354

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Cat No: 17290

Biochemicals - Kinase Inhibitors

IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation.{28402} It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-benzamide

Correlated keywords:

634914-41-3 NF-?B IKK? IKK2 inhibitor ischemia reperfusion cancer apoptosis biochemical cardiology inhibit intracellular signaling protein kinase IKK-? IKK-2 phosphorylation p65 nuclear translocation cardioprotective P-selectin ICAM-1 ICAM1 cardiomyocyte IL-1? IL1? MCP-1 MCP1 neutrophil accumulation injury human breast cancer cell cycle arrest chronic lymphocytic leukemia pathway anti-apoptotic gene antiapoptotic proapoptotic NF?B

Product Overview:
IMD 0354 is an IKKβ (IKK2) inhibitor that blocks NF-κB phosphorylation (IC50 = ~250 nM) and subsequent NF-κB p65 nuclear translocation.{28402} It exhibits cardioprotective properties by decreasing expression of P-selectin and ICAM-1 in the vasculature and blocking cardiomyocyte IL-1β and MCP-1 production, resulting in suppressed neutrophil accumulation in a rat model of ischemia/reperfusion injury.{28402} IMD 0354, suppresses the growth of human breast cancer cells by inducing cell cycle arrest and apoptosis.{28404} It induces apoptosis of chronic lymphocytic leukemia cells at 1-10 µM by directly targeting the NF-κB pathway, decreasing expression of anti-apoptotic genes and increasing expression of proapoptotic genes.{28403}

Size	1 mg
Shipping	dry ice
CAS Number	978-62-1
Molecular Formula	C₁₅H₈ClF₆NO₂
SMILES	O=C(C1=C(O)C=CC(Cl)=C1)NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2
Molecular Weight	383,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.