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Toll-Like Receptor 7 Ligand II

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    Toll-Like Receptor 7 Ligand II
  • Toll-Like Receptor 7 Ligand II
Cat No: 17228
Biochemicals - Receptor Pharmacology
Cayman

A potential treatment for hepatitis C virus (HCV) is to induce immune cell-derived interferon (IFN) production using synthetic agonists of toll-like receptor 7 (TLR7). TLR7 ligand II is an orally bioavailable 8-hydroxyadenine analog that induces IFN pr...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 6-amino-7,9-dihydro-2-(2-methoxyethoxy)-9-(phenylmethyl)-8H-purin-8-one
Correlated keywords:
  • toll-like TLR7 ligand 1V136 CL 087 SM 360320 CL087 SM360320 TLR-7 toll like HCV hepatitis C virus IFN immune cell derived interferon analog 8-hydroxyadenine agonist receptor immunology infectious disease antiviral biochemical IFN? peripheral blood mononuclear Huh7 Huh-7 hepatocyte replicon orally bioavailable imiquimod
Product Overview:
A potential treatment for hepatitis C virus (HCV) is to induce immune cell-derived interferon (IFN) production using synthetic agonists of toll-like receptor 7 (TLR7). TLR7 ligand II is an orally bioavailable 8-hydroxyadenine analog that induces IFN production by binding to TLR7 on immune cells.{28465,28466} It induces IFNα in human peripheral blood mononuclear cells with an EC50 value of 0.14 µM.{28466} At 10 µM, TLR7 ligand II was shown to reduce HCV levels by 60% in 24 hours in the human hepatocyte cell line Huh7, which carries a HCV replicon.{28467} It induces IFN in mice with a minimal effective dose of approximately 0.03 mg/kg, making it approximately 100-fold more potent than imiquimod (Item No. 14956).{28465}
Size 500 µg
Shipping dry ice
CAS Number 226907-52-4
Molecular Formula C15H17N5O3
SMILES COCCOC1=NC(N)=C2C(N(CC3=CC=CC=C3)C(N2)=O)=N1
Molecular Weight 315,3
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.59
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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