4-oxo-2-Nonenal Alkyne

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Cat No: 17104

4-oxo-2-Nonenal (4-ONE, Item No. 10185) is a product of lipid peroxidation that actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{9278,11422,11421,11420,11419} It also modifies 2'-deoxyguanosine, further impl...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(E)-4-oxonon-2-en-8-ynal

Correlated keywords:

1680193-58-1 ROS alkyne click chemistry free radical peroxidation lipid autoxidation reactive oxygen species biochemical cancer oxidative injury oxylipin probe alkyne-tagged aONE a-ONE a4ONE 4-oxononenal alkyne

Product Overview:
4-oxo-2-Nonenal (4-ONE, Item No. 10185) is a product of lipid peroxidation that actively modifies histidine and lysine residues on proteins and causes protein cross-linking.{9278,11422,11421,11420,11419} It also modifies 2'-deoxyguanosine, further implicating lipid peroxidation in mutagenesis and carcinogenesis.{9278} 4-ONE alkyne is an alkyne-tagged electrophile that can be used as a probe to isolate and identify the reaction products of lipid peroxidation using click chemistry.{26588,26526}

Size	100 µg
Shipping	dry ice
CAS Number	1680193-58-1
Molecular Formula	C₉H₁₀O₂
SMILES	[H]C(/C=C/C(CCCC#C)=O)=O
Molecular Weight	150,2
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2912.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.