KD 025

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KD 025

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Cat No: 17055

Biochemicals - Kinase Inhibitors

KD 025 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = 0.105 µM).{28734} It is selective for ROCK2 over ROCK1 (IC50 = 24 µM). KD 025 (10 µM) decreases the expression of connective tissue growth factor (CTGF) and induces remodeling of the act...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[3-[4-(1H-indazol-5-ylamino)-2-quinazolinyl]phenoxy]-N-(1-methylethyl)-acetamide

Correlated keywords:

911417-96-4 1243152-02-4 biochemical inhibitor inhibit signal transduction intracellular signaling cytoskeletal research inflammation autoimmune disease immunology Rho-associated protein kinase 2 ROCKII ROCK II KD025 SLx2119 Belumosudil

Product Overview:
KD 025 is an inhibitor of Rho-associated kinase 2 (ROCK2; IC50 = 0.105 µM).{28734} It is selective for ROCK2 over ROCK1 (IC50 = 24 µM). KD 025 (10 µM) decreases the expression of connective tissue growth factor (CTGF) and induces remodeling of the actin cytoskeleton in isolated human ileal fibrotic smooth muscle cells. It inhibits heat-killed C. albicans- or S. epidermidis-induced production of IL-17 in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 1.25 to 10 µM.{58833} KD 025 (100 and 200 mg/kg) reduces infarct volume in a mouse model of cerebral ischemia induced by transient middle cerebral artery occlusion (MCAO).{28726} It decreases disease severity in a mouse model of sclerodermatous chronic graft versus host disease (GVHD) when administered at a dose of 150 mg/kg.{58834} Formulations containing KD 025 have been used in the treatment of chronic GVHD.

Size	10 mg
Shipping	dry ice
CAS Number	911417-87-3
Molecular Formula	C₂₆H₂₄N₆O₂
SMILES	O=C(NC(C)C)COC1=CC=CC(C2=NC3=CC=CC=C3C(NC4=CC(C=NN5)=C5C=C4)=N2)=C1
Molecular Weight	452,5
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.