3-(4-Pyridyl)indole

Biochemicals - Kinase Inhibitors

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Cat No: 17922

Biochemicals - Kinase Inhibitors

Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contractio...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(4-pyridinyl)-1H-indole

Correlated keywords:

69679-78-3 69214-97-7 ROCKI ROCKII PRK MSK1

Product Overview:
Two Rho-associated kinases (ROCK), ROCK1 and ROCK2, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.{17734,17735,17322} 3-(4-Pyridyl)indole is a ROCK1 inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay.{29128} It also inhibits ROCK2 and PRK2, another Rho-dependent kinase, with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency.{29128}

Size	5 mg
Shipping	dry ice
CAS Number	7272-84-6
Molecular Formula	C₁₃H₁₀N₂
SMILES	C12=CC=CC=C1NC=C2C3=CC=NC=C3
Molecular Weight	194,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.39
UNSPSC code	12352100

Technical File

MSDS

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