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SP 141

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    SP 141
  • SP 141
Cat No: 17003
Biochemicals - Small Molecule Inhibitors
Cayman

Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome.{11628} SP 141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM).{27642} Binding...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 6-methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
Correlated keywords:
  • biochemical inhibitor apoptosis cancer cell cycle intracellular signaling ubiquitin-proteasome inhibit mdm2 mouse double minute 2 protein SP141 AGNPC0D106I AGNPC 0D106I
Product Overview:
Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome.{11628} SP 141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM).{27642} Binding of MDM2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation.{27642,29204} SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo.{27642,29204} This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.{29203}
Size 1 mg
Shipping dry ice
CAS Number 1253491-42-7
Molecular Formula C22H16N2O
SMILES COC1=CC2=C(C=C1)NC(C2=CC=N3)=C3C4=C(C=CC=C5)C5=CC=C4
Molecular Weight 324,4
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.19
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : SP 141 There are 7 products.

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