Binimetinib

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Binimetinib

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Cat No: 16996

Biochemicals - Kinase Inhibitors

Binimetinib is an orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM).{27962} It has been found to inhibit ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM).{27962} This compound is efficacious in several xenograft tumor models in mic...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide

Correlated keywords:

inhibitor MEK1/2 ERK cancer signal transduction kinase intracellular signaling inhibit biochemical ARRY162 ARRY 162 phosphorylation cell line xenograft tumor K-Ras KRas B-Raf BRaf mutation N-Ras NRas melanoma lung biliary tract

Product Overview:
Binimetinib is an orally bioavailable inhibitor of MEK1/2 (IC50 = 12 nM).{27962} It has been found to inhibit ERK phosphorylation in various cancer cell lines (IC50s ≥ 5 nM).{27962} This compound is efficacious in several xenograft tumor models in mice, including those bearing K-Ras or B-RAF mutations, and has been characterized in clinical studies using patients with N-Ras melanoma, non-small cell lung cancer, or biliary tract cancer.{27962,27963,27940}

Size	5 mg
Shipping	dry ice
CAS Number	606143-89-9
Molecular Formula	C₁₇H₁₅BrF₂N₄O₃
SMILES	BrC1=CC(F)=C(NC2=C(F)C(N=CN3C)=C3C=C2C(NOCCO)=O)C=C1
Molecular Weight	441,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.