Ranitidine (hydrochloride)

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Cat No: 16939

Biochemicals - Receptor Pharmacology

Ranitidine is a histamine H2 receptor antagonist.{27474} It reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2)....

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N'-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N-methyl-2-nitro-1,1-ethenediamine, monohydrochloride

Correlated keywords:

gastroprotective H2 H-2 antihistamine 70956-04-6 80020-48-0 86386-78-9 66357-35-5 AH 19065 AH19065 Zantab Zantadin Zantic Zinetac Zintac Achedos Acidex Aciloc Acloral Aldin Anistal Antagonin Apo-Ranitidine Aporanitidine Apozan Atural Axoban Azantac Consec Coralen Curan Eltidine Galidrin Gastrial Gastridin Gastrosedol Histac Histak Lydin Melfax Microtid Neoceptin R NeoceptinR Noctone Normon Ptinolin Quantor Quicran RND Radinat Ranacid Randin Rani 2 Rani2 Ranial Raniben Ranidil Ranidine Ranigast Ranimex Ranin Raniogas Raniplex Ranisen Ranitab Ranital akri Ranitiget Ranitin Ranix Rantac Rantacid Rantidol Rantin Ranuber Ratic Raticina Rosimol Simetac Sostril Taural Terposen Trigger Ul-Pep Ulceran Ulceranin Ulcex Ulcirex Ulsal Ultac Ultidine Urantac Verlost Vesyca Vizerul Weichilin Weidos Xanidine reduction reduce inhibit inhibitor hydrogen ion concentration intracellular cAMP production treatment Ezopta Zantac

Product Overview:
Ranitidine is a histamine H2 receptor antagonist.{27474} It reverses histamine-induced relaxation of isolated rat uterine horn (pA2 = 6.9) as well as histamine-induced increases in contraction frequency in isolated guinea pig right atrium (pA2 = 7.2). Ranitidine (0.03-3 mg/kg, i.v.) inhibits histamine-and pentagastrin-induced gastric acid secretion in a dose-dependent manner in anesthetized rats. Formulations containing ranitidine have been used in the treatment and preventrion of heartburn and gastroesophageal reflux disease (GERD).

Size	1 g
Shipping	dry ice
CAS Number	66357-59-3
Molecular Formula	C₁₃H₂₂N₄O₃S • HCl
SMILES	CN/C(NCCSCC1=CC=C(CN(C)C)O1)=C\[N+]([O-])=O.Cl
Molecular Weight	350,9
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2921.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.