Oxolinic Acid

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Oxolinic Acid

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Cat No: 16789

Biochemicals - Small Molecule Inhibitors

Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA.{22833,27399} Oxolinic acid is a quinolone antibiotic that inhibits bacterial DNA gyrase, but not eukaryotic topoisomerases, reversibl...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-ethyl-5,8-dihydro-8-oxo-1,3-dioxolo[4,5-g]quinoline-7-carboxylic acid

Correlated keywords:

81032-31-7 1135442-99-7 biochemical antibiotic inhibitor neuroscience DNA damage repair Dioxacin Emyrenil Gramurin Inoxyl NSC110364 Nidantin Ossian Oxoboi Pietil Prodoxal Prodoxol S 0208 S0208 Starner 20WP Ultibid Uritrate Uro-Alvar Uroalvar Urotrate Uroxin Uroxol Utibid W 4565 W4565 bacterial deoxyribonucleic gyrase heterodimeric type II 2 topoisomerase reversibly binding subunit A complex blocking inhibit inhibiting synthesis neuronal uptake dopamine mammal locomotor activity

Product Overview:
Bacterial DNA gyrase is a heterodimeric type II topoisomerase that negatively supercoils circular double-stranded DNA.{22833,27399} Oxolinic acid is a quinolone antibiotic that inhibits bacterial DNA gyrase, but not eukaryotic topoisomerases, reversibly binding gyrase subunit A in gyrase-DNA complexes, blocking supercoiling activity and inhibiting DNA synthesis at 0.5-5 µg/ml.{22833,27401,27400} Oxolinic acid also blocks neuronal uptake of dopamine in mammals (IC50 = 4.3 µM), leading to an increase in locomotor activity.{27402}

Size	1 g
Shipping	dry ice
CAS Number	14698-29-4
Molecular Formula	C₁₃H₁₁NO₅
SMILES	CCN1C=C(C(O)=O)C(C2=CC3=C(OCO3)C=C21)=O
Molecular Weight	261,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.