15-keto Fluprostenol isopropyl e

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15-keto Fluprostenol isopropyl ester

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Cat No: 16786

Biochemicals - Lipids

Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.{8839,9613} Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto trav...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(±)-15-oxo-9?,11?-dihydroxy-16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, isopropyl ester

Correlated keywords:

glaucoma metabolites eyes ophthalmology ophthalmological 15-keto-fluprostenol IOP intraocular pressure hypotensive esters

Product Overview:
Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.{8839,9613} Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response.{3586} The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.

Size	1 mg
Shipping	dry ice
CAS Number	404830-45-1
Molecular Formula	C₂₆H₃₃F₃O₆
SMILES	O[C@@H]1[C@H](C/C=C\CCCC(OC(C)C)=O)[C@@H](/C=C/C(COC2=CC(C(F)(F)F)=CC=C2)=O)[C@H](O)C1
Molecular Weight	498,5
Formulation	A solution in methyl acetate
Purity	≥98%
Custom Code	2937.50
UNSPSC code	12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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