AZ 960

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AZ 960

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Cat No: 16731

Biochemicals - Kinase Inhibitors

Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch fro...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5-fluoro-?2-?[[(1S)-?1-?(4-?fluorophenyl)?ethyl]?amino]?-?6-?[(5-?methyl-?1H-?pyrazol-?3-?yl)?amino]-3-pyridinecarbonitrile

Correlated keywords:

Janus-associated kinase JAK2 myeloproliferative disease V617F mutation leukemia lymphoma ATL cancer signal transduction apoptosis Bcl-2 inhibit JAK 2 cytoplasmic cytoplasm tyrosine signaling cytokine growth factor receptor mutation valine phenylalanine aggressive adult T cell leukemia lymphoma in vitro STAT3/5 phosphorylation proliferation SET-2 two human megakaryoblastic line induce death lymphotropic virus type 1-infected downregulation downregulate down regulate family protein Bcl2 AZ960 SET2 AZ 960

Product Overview:
Janus-associated kinases (JAKs) are cytoplasmic tyrosine kinases that are required for activating the signaling of certain cytokines and growth factor receptors. Many myeloproliferative diseases have been linked to a mutation in JAK2 where a switch from valine to phenylalanine occurs at the 617 position (V617F).{27171} Furthermore, constitutive activation of the JAK2 signaling pathway is associated with aggressive adult T cell leukemia/lymphoma.{27172} AZ 960 inhibits JAK2 with a Ki value of 0.45 nM in vitro.{27171} It can decrease STAT3/5 phosphorylation and inhibit cell proliferation in a SET-2 human megakaryoblastic cell line that is heterozygous for the JAK2 V617F mutation with a GI50 value of 33 nM.{27171} AZ 960 can also induce apoptosis in human T cell lymophotropic virus type 1-infected (IC50 = ~1 µM), which corresponds to a downregulation of phosphorylated forms of JAK2 and Bcl-2 family proteins.{27172}

Size	1 mg
Shipping	dry ice
CAS Number	905586-69-8
Molecular Formula	C₁₈H₁₆F₂N₆
SMILES	FC1=CC=C([C@H](C)NC2=C(C#N)C=C(F)C(NC3=NNC(C)=C3)=N2)C=C1
Molecular Weight	354,4
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2837.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.