ZM 39923 (hydrochloride)

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Cat No: 16729

Biochemicals - Kinase Inhibitors

ZM 39923 is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 µM, respectively).{27341} In the absence of the reducing agent dithiothreitol, Z...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)-1-propanone, monohydrochloride

Correlated keywords:

273727-89-2 biochemical inflammation inhibitor arthritis signal transduction protein kinase inhibit potent JAK3 JAK 3 janus non-receptor nonreceptor signaling cytokine transducer activator transcription Stat family ZM39923 epidermal growth factor JAK1 1 cyclin-dependent 4 reducing agent dithiothreitol human tissue transglutaminase 2 TGM2 TGM factor XIIIa ZM 449829 ZM449829

Product Overview:
ZM 39923 is an inhibitor of JAK3 (IC50 = 79 nM) that less potently inhibits epidermal growth factor receptor, JAK1, and cyclin-dependent kinase 4 (IC50s = 2.4, 40, and 10 µM, respectively).{27341} In the absence of the reducing agent dithiothreitol, ZM 39923 also inhibits human tissue transglutaminase 2 (TGM2) and the transglutaminase Factor XIIIa (IC50s= 10 and 25 nM, respectively).{22726} It breaks down in neutral buffer to form ZM 449829, which is also an inhibitor of JAK3, TGM2, and Factor XIIIa.{27341,22726}

Size	1 mg
Shipping	dry ice
CAS Number	1021868-92-7
Molecular Formula	C₂₃H₂₅NO • HCl
SMILES	O=C(CCN(CC1=CC=CC=C1)C(C)C)C2=CC3=CC=CC=C3C=C2.Cl
Molecular Weight	367,9
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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