SLIGRL-NH2 (trifluoroacetate sal

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SLIGRL-NH₂ (trifluoroacetate salt)

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Cat No: 16723

Biochemicals - Receptor Pharmacology

Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is cleaved by serine proteases, resulting in self-activation of the receptor by a tethered ligand.{27549,27550} The ligand corresponds to residues 39-44 (SLIGRL in mouse PAR-2)...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

L-seryl-L-leucyl-L-isoleucylglycyl-L-arginyl-L-Leucinamide, trifluoroacetate salt

Correlated keywords:

171436-38-7 protein receptor agonist pain signal transduction immunology inflammation vascular disease SLIGRLNH2 recombinant peptide activate PAR-2 PAR2 stimulate gastric intestinal smooth muscle contraction induce thermal hyperalgesia mice cells SL-NH2 SLNH2 biochemical

Product Overview:
Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is cleaved by serine proteases, resulting in self-activation of the receptor by a tethered ligand.{27549,27550} The ligand corresponds to residues 39-44 (SLIGRL in mouse PAR-2).{27549,27550} SLIGRL-NH2 is a recombinant peptide that activates PAR2 (EC50 = ~5 µM), without requiring receptor cleavage.{27549,27550} This peptide does not activate PAR1. Through its effects on PAR2, SLIGRL-NH2 stimulates gastric and intestinal smooth muscle contraction and induces thermal hyperalgesia in mice.{27547,27548} SLIGRL-NH2 is used to explore signaling through PAR2 in cells and in animals.{27551,27546}

Size	500 µg
Shipping	dry ice
Molecular Formula	C₂₉H₅₆N₁₀O₇ • XCF₃COOH
SMILES	NC(NCCC[C@H](NC(CNC([C@H]([C@H](CC)C)NC([C@@H](NC([C@H](CO)N)=O)CC(C)C)=O)=O)=O)C(N[C@H](C(N)=O)CC(C)C)=O)=N.FC(F)(C(O)=O)F
Molecular Weight	656,8
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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SLIGRL-NH2 (trifluoroacetate salt)