P7C3 - C21H18Br2N2O - Bertin Bioreagent

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P7C3

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Cat No: 16682

Biochemicals - More Biochemicals

P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus.{27449} At ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,6-dibromo-?-[(phenylamino)methyl]-9H-carbazole-9-ethanol

Correlated keywords:

neural stem cells neuroprotection neuron neurodengeneration nerve injury NAMPT NAD Alzheimer?s disease research Parkinson’s neuroscience biology biochemical proneurogenic neuroprotective compound P7-C3 P-7C3 P7C-3 P-7-C-3 orally bioavailable brain penetrant aminopropyl carbazole preventing apoptosis postmitotic subgranular zone hippocampal dentate gyrus promote survival rodent model bind nicotinamide phosphoribosyltransferase rate-limiting enzyme conversion adenine dinucleotide

Product Overview:
P7C3 is an orally bioavailable and brain penetrant aminopropyl carbazole that exhibits proneurogenic and neuroprotective activity by preventing apoptosis of newly postmitotic neurons in the subgranular zone of the hippocampal dentate gyrus.{27449} At doses of 5 mg/kg and above, it has been shown to promote the survival of neurons in various rodent models of neurodegeneration or nerve injury.{27447,27448} While the precise mechanism of action through which these effects are exerted remains uncertain, P7C3 recently has been shown to bind nicotinamide phosphoribosyltransferase, the rate-limiting enzyme involved in the conversion of nicotinamide into NAD.{27340}

Size	5 mg
Shipping	dry ice
CAS Number	301353-96-8
Molecular Formula	C₂₁H₁₈Br₂N₂O
SMILES	BrC(C=C1)=CC2=C1N(CC(CNC3=CC=CC=C3)O)C4=CC=C(Br)C=C42
Molecular Weight	474,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.