Rhodamine 123 (chloride)

Confirm delete?

Zoom

Cat No: 16672

Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells.{27856} It is a substrate for the efflux pump P-glycoprotein (P-gp; also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from...

This product can only be bought through Cayman Chemical. Please contact us.

Product Overview
Data
Downloads
About Cayman

Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3,6-diamino-9-[2-(methoxycarbonyl)phenyl]-xanthylium, monochloride

Correlated keywords:

104114-27-4 108608-?81-?7 140686-?88-?0 1167436-?73-?8 RH123 RH 123 biochemical dye cancer mitochondria stem cells research stain indicator biology membrane permeable cationic dye Rhodamine123 accumulate efflux pump substrate P-glycoprotein P-gp Pgp multidrug resistance protein1 protein 1 ABCB1 side population detect detection study localize

Product Overview:
Rhodamine 123 is a membrane-permeable cationic dye that is readily accumulated within living cells.{27856} It is a substrate for the efflux pump P-glycoprotein (P-gp; also known as multidrug resistance protein 1 and ABCB1) and is rapidly exported from cells with functional P-gp.{27854,27855} As P-gp is expressed on a population of stem cells known as the side population, rhodamine 123 is used to detect this group of stem cells.{27855,27857} Rhodamine 123 also accumulates within mitochondria due to its positive charge and can inhibit oxidative phosphorylation.{27856,27853} Rhodamine 123 has excitation/emission maxima of 507/529 nm.{42160}

Size	5 mg
Shipping	dry ice
CAS Number	62669-70-9
Molecular Formula	C₂₁H₁₇N₂O₃ • Cl
SMILES	NC1=CC2=[O+]C3=C(C(C4=CC=CC=C4C(OC)=O)=C2C=C1)C=CC(N)=C3.[Cl-]
Molecular Weight	380,8
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

Technical File

MSDS

Click here to ask for your quote and get 15% off Cayman's products.

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.