Melphalan

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Melphalan

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Cat No: 16665

Biochemicals - Dna Alkylating Agents

Melphalan is a phenylalanine derivative of mechlorethamine, belonging to the family of nitrogen mustard alkylating agents that are used for chemotherapy.{26270} It attaches an alkyl group to guanine bases in DNA at the 7-nitrogen of the imidazole ring...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

4-[bis(2-chloroethyl)amino]-L-phenylalanine

Correlated keywords:

8057-25-8 3223-07-2 531-76-0 anticancer cytotoxic DNA crosslinking chemotherapy apoptosis alkylating agent biochemical cancer damage repair inhibitor deoxyribonucleic acid mechlorethamine alanine mustard agent alkylation group guanine base 7-nitrogen seven N imidazole ring interstrand intrastrand crosslinks cytotoxicity apoptosis programmed cell death growth PC-3 PC3 prostate dose alanine nitrogen mustard Alkeran CB 3025 CB3025 L-PAM L-Phenylalanine mustard hydrochloride L-Sarcolysine L-Sarkolysin Levofalan Levofolan Levopholan Melfalan NSC 241286 NSC 8806 NSC241286 NSC8806 Sarcoclorin

Product Overview:
Melphalan is a phenylalanine derivative of mechlorethamine, belonging to the family of nitrogen mustard alkylating agents that are used for chemotherapy.{26270} It attaches an alkyl group to guanine bases in DNA at the 7-nitrogen of the imidazole ring, which leads to DNA interstrand and intrastrand crosslinks, cytotoxicity, and apoptosis.{26270} Melphalan can inhibit the growth of PC-3 prostate cancer cells with IC50 values of 0.074 or 0.77 μM for sequential dosing or single dosing, respectively.{27295}

Size	50 mg
Shipping	dry ice
CAS Number	148-82-3
Molecular Formula	C₁₃H₁₈Cl₂N₂O₂
SMILES	OC([C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1)=O
Molecular Weight	305,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.