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SB-590885

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    SB-590885
  • SB-590885
Cat No: 16643
Biochemicals - Kinase Inhibitors
Cayman

B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling.{27148} Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi.{27148} SB-590885 is a potent...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 5-[2-[4-[2-(dimethylamino)ethoxy]phenyl]-5-(4-pyridinyl)-1H-imidazol-4-yl]-2,3-dihydro-1H-inden-1-one oxime
Correlated keywords:
  • cancer inhibitors signal transduction cell intracellular biochemical BRaf MAP kinase MAPKKK Ras family GTPase MEK1/2 ERK1/2 mutation Val600 melanoma melanocytic nevi SB590885 inhibit block activation anchorage-independent cell proliferation wild type V600E B-RafV600E invasion cerebral ischemia
Product Overview:
B-Raf is a MAP kinase kinase kinase, which functions downstream of Ras family GTPases to activate MEK1/2 and ERK1/2 signaling.{27148} Mutations of B-Raf, particularly at Val600, are common in melanomas and melanocytic nevi.{27148} SB-590885 is a potent inhibitor of B-Raf (Kd = 0.3 nM).{27151} It less effectively inhibits c-Raf (Ki = 1.72 nM) and has little effect at 46 other kinases.{27151,27149} SB-590885 blocks activation of ERK1/2 and anchorage-independent cell proliferation of melanoma cells with either wild type or V600E B-Raf at nanomolar concentrations.{27149,27150} Melanoma cells expressing the B-RafV600E mutation can drive invasion through alternative pathways in the presence of SB-590885, suggesting that combination therapy is needed to completely block cell invasion.{27150} SB-590885 has also been used to study the role of B-Raf in cerebral ischemia.{27152}
Size 1 mg
Shipping dry ice
CAS Number 405554-55-4
Molecular Formula C27H27N5O2
SMILES CN(C)CCOC1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C(/C(CC5)=N/O)C5=C4)N2)C=C1
Molecular Weight 453,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.29
UNSPSC code 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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