D-Mannoheptulose

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D-Mannoheptulose

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Cat No: 16548

Biochemicals - Small Molecule Inhibitors

D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucos...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

D-manno-2-heptulose

Correlated keywords:

inhibitors carbohydrate research diabetes obesity metabolism biochemical glucokinase hexokinase heptose inhibits competition competes D-glucose blocks glucose oxidation glucose-mediated insulin release pancreatic islet cells prevents convert conversion glucose-6-phosphate activator activate carbohydrate response element binding protein phosphorylation hyperglycemia dogs postprandial energy expenditure increase NSC226836 (+)-mannoheptulose

Product Overview:
D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM).{27136,27134,27137} It blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells.{27135,27138} D-Mannoheptulose prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein.{27139} By blocking glucose phosphorylation, D-mannoheptulose causes transient hyperglycemia in dogs when given at 1 g/kg but not at 8 mg/kg, although postprandial energy expenditure is increased at the lower dose.{27140}

Size	5 mg
Shipping	dry ice
CAS Number	3615-44-9
Molecular Formula	C₇H₁₄O₇
SMILES	OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)C(CO)=O
Molecular Weight	210,2
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2912.49
UNSPSC code	12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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