Glycopyrrolate

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Glycopyrrolate

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Cat No: 16498

Biochemicals - Receptor Pharmacology

Glycopyrrolate is an antagonist of muscarinic acetylcholine receptors (mAChRs; Kis = 0.42, 1.77, 0.52, 0.78, and 1.29 nM for the M1-M5 receptors, respectively).{57838} It induces relaxation of precontracted isolated human bronchi when used at concentr...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[(2-cyclopentyl-2-hydroxy-2-phenylacetyl)oxy]-1,1-dimethyl-pyrrolidinium, monobromide

Correlated keywords:

13283-82-4 ulcer anti-cholinergic anticholinergic bronchodilator COPD asecryl copyrrolate gastrodyn glycopyrrone-bromide glycopyrronium-bromide NVA-237 NVA237 nodapton robanul robinul seebri tarodyl tarodyn QVA-149 QVA149 muscarinic long-acting antispasmodic anti-spasmodic gastrointestinal drooling anesthetic chronic obstructive pulmonary NSC250836 NSC251251 NSC251252 AHR504

Product Overview:
Glycopyrrolate is an antagonist of muscarinic acetylcholine receptors (mAChRs; Kis = 0.42, 1.77, 0.52, 0.78, and 1.29 nM for the M1-M5 receptors, respectively).{57838} It induces relaxation of precontracted isolated human bronchi when used at concentrations of 0.01, 0.1, or 1 µM.{61751} Glycopyrrolate reduces post-prandial gastric antral motility in dogs when administered at a dose of 0.01 mg/kg.{57839} It inhibits salivation in a rat model of sialorrhea induced by pilocarpine with an ED50 value of 0.74 µg/kg.{61751} Formulations containing glycopyrrolate have been used in the treatment of sialorrhea, peptic ulcers, and chronic obstructive pulmonary disease (COPD).

Size	5 mg
Shipping	dry ice
CAS Number	596-51-0
Molecular Formula	C₁₉H₂₈NO₃ • Br
SMILES	O=C(OC1CC[N+](C)(C)C1)C(O)(C2=CC=CC=C2)C3CCCC3.[Br-]
Molecular Weight	398,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2902.90
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.