Hemin chloride

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Hemin chloride

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Cat No: 16487

Biochemicals - Kinase Inhibitors

Hemin chloride is an oxidized form of heme that inhibits eukaryotic translation initiation factor 2α kinase 1 (eIF2αK1), a repressor of eIF-2α.{32368} This alters the initiation of mRNA translation, evoking a wide array of cellular effects. Hemin chlo...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(SP-5-13)-chloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,8-dipropanoato(4-)-?N21, ?N22, ?N23, ?N24]-ferrate(2-), dihydrogen

Correlated keywords:

752166-39-5 35-?08-?5 13408-?65-?6 15489-?47-?1 20814-?13-?5 58248-?97-?8 63452-?72-?2 79266-?76-?5 83603-?95-?6 210561-?76-?5 1160714-?75-?9 heme eurkaryotic translation initiation oxidized eIF2?K1 eIF-2? eIF2? mRNA oxygenase-1 porphyrin porphyria ?-aminolevulinic protohemin-IX chlorohemin chloroprotoferriheme chloroprotohemin ferric-hemin ferriheme chloride ferriporphyrin ferriprotoporphyrin ferriprotoporphyrin-IX hemin-IX iron(III)-protoporphyrin KJB-003 panhematin protoferriheme protohemin Teichmann's crystals haemin chloroferriprotoporphyrin

Product Overview:
Hemin chloride is an oxidized form of heme that inhibits eukaryotic translation initiation factor 2α kinase 1 (eIF2αK1), a repressor of eIF-2α.{32368} This alters the initiation of mRNA translation, evoking a wide array of cellular effects. Hemin chloride is used experimentally to induce the expression of heme oxygenase-1 in cells and in animals.{32369,32367,32365} Heme extracted from blood is usually oxidized to hemin chloride.{32366,32364} In porphyria, disorders resulting from an increase in porphyrins, hemin chloride serves to activate feedback inhibition of δ-aminolevulinic acid synthase, reducing heme biosynthesis.{32364}

Size	1 g
Shipping	dry ice
CAS Number	16009-13-5
Molecular Formula	C₃₄H₃₀ClFeN₄O₄ • 2H
SMILES	[O-]C(CCC1=C(C=C2[N]3=C4C(C)=C2CCC([O-])=O)[N-]([Fe+3]35([Cl-])[N]6=C7C=C(C(C=C)=C8C)[N-]5C8=C4)C(C=C6C(C=C)=C7C)=C1C)=O.[H+].[H+]
Molecular Weight	652
Formulation	A crystalline solid
Purity	≥96%
Custom Code	2827.39
UNSPSC code	12352100

Technical File

MSDS

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