Pyrimethamine

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Pyrimethamine

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Cat No: 16472

Pyrimethamine is an antiprotozoal agent that is primarily active against P. falciparum, inhibiting the protozoal enzyme dihydrofolate reductase (DHFR).{26927} By blocking DHFR activity, pyrimethamine prevents the production of tetrahydrofolic acid, an...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

5,4-chlorophenyl-6-ethyl-2,4-pyrimidinediamine

Correlated keywords:

antimalarial antiprotozoal anti-protozoal anti protozoal enzymes dihydrofolates reductases DHFRs inhibitors tetrahydrofolic acids folates pathways SOD1s superoxide dismutases 1s amyotrophic laterals sclerosis ALS infectious diseases biochemicals P falciparum Plasmodium Pfalciparum blocking blocks blockers activity activities prevents preventions productions coenzymes DNAs RNAs synthesis in vivo mouse models prophylactics effects sulphonamides synergistically synergistic arresting arrests arrested limits limited expressions genes BWs 50-63 BW50-63 5063 4753 RP 4753RP 4753-RP RP-4753 RP4753 Chloridine Chloridine Darachlor Daraprime Diaminopyritamin Erbaprelina Malacid Malocid Malocide NSCs 3061 NSC-3061 NSC3061 Pirimecidan Pirimetamin Pyrimethamin Tindurin Tinduring WRs 2978 WR-2978 WR2978 Chloridin

Product Overview:
Pyrimethamine is an antiprotozoal agent that is primarily active against P. falciparum, inhibiting the protozoal enzyme dihydrofolate reductase (DHFR).{26927} By blocking DHFR activity, pyrimethamine prevents the production of tetrahydrofolic acid, an essential coenzyme involved in DNA and RNA synthesis. In in vivo antimalarial mouse models, pyrimethamine displays a prophylactic effect at an ED50 value of 0.5 mg/kg.{26925} Sulphonamides act synergistically with pyrimethamine by arresting production of dihydrofolic acid, resulting in the sequential blockade of the folate pathway of protozoa.{26897} Pyrimethamine has also been found to limit the expression of the superoxide dismutase 1 (SOD1) gene, a metalloenzyme involved in amyotrophic lateral sclerosis.{26926}

Size	10 mg
Shipping	dry ice
CAS Number	58-14-0
Molecular Formula	C₁₂H₁₃ClN₄
SMILES	ClC1=CC=C(C2=C(CC)N=C(N)N=C2N)C=C1
Molecular Weight	248,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2922.19
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.