1-methyl-D-Tryptophan

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Cat No: 16456

Biochemicals - Small Molecule Inhibitors

Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-methyl-D-tryptophan

Correlated keywords:

inhibitors cancers D-(+)-1-methyltryptophan D-1-methyltryptophan methyltryptophan D 1 + methyl tryptophan inhibits inhibitions indoleamine 2,3-dioxygenase IDO dioxygenases 2 3 metabolizes kynurenine NAD+ NAD pathways overexpressions tumors tumor-draining draining lymph nodes immunes tolerances growths in vivo mice prevents T cells T-cell anergy dendritic antitumor anti-tumor immunoresponses CD8+ CD8 xenografts chemotherapy regressions survivals humans ovarians carcincomas SKOV-3 SKOV3 SKOV cultures antiviral anti-viral virals indoximod NLG8189 NL-G8189

Product Overview:
Indoleamine 2,3-dioxygenase (IDO) metabolizes tryptophan to kynurenine, leading to the production of NAD+ via the kynurenine pathway. The overexpression of IDO in tumors and tumor-draining lymph nodes induces immune tolerance and enhances tumor growth in vivo.{26962,26961} 1-methyl-D-Tryptophan is an inhibitor of IDO (IC50 = 7 µM) that is effective in vivo.{26963,26959} In mice, 1-methyl-D-tryptophan prevents T-cell anergy triggered by dendritic cells overexpressing IDO.{26959} It augments the antitumor and antiviral immunoresponse of CD8+ T-cells and reduces tumor volume in mice with xenografts overexpressing IDO.{26962,26961} 1-methyl-D-Tryptophan, in combination with chemotherapy, causes regression of tumors and prolongs survival.{26962,26960} Surprisingly, 1-methyl-D-tryptophan induces the expression of IDO in human ovarian carcinoma SKOV3 cells in culture.{26960}

Size	250 mg
Shipping	dry ice
CAS Number	110117-83-4
Molecular Formula	C₁₂H₁₄N₂O₂
SMILES	CN1C2=CC=CC=C2C(C[C@H](C(O)=O)N)=C1
Molecular Weight	218,3
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2915.90
UNSPSC code	12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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