NSC 66811

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NSC 66811

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Cat No: 16431

Biochemicals - Small Molecule Activators

NSC 66811 is a potent inhibitor of murine double minute 2 (Mdm2) interaction with p53 by binding Mdm2 (Ki = 120 nM), in this way activating p53.{31195} NSC 66811 induces the accumulation of p21, p53, and Mdm2 in human colon cancer cells in vitro. Inhi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-methyl-7-[phenyl(phenylamino)methyl]-8-quinolinol

Correlated keywords:

899821-36-4 899821-37-5 NSC66811 NSC66811 Mdm2-p53 interaction Mdm2p53 Mdm-2p53 murine double minute 2 p53 p-53 p-21 Mdm-2

Product Overview:
NSC 66811 is a potent inhibitor of murine double minute 2 (Mdm2) interaction with p53 by binding Mdm2 (Ki = 120 nM), in this way activating p53.{31195} NSC 66811 induces the accumulation of p21, p53, and Mdm2 in human colon cancer cells in vitro. Inhibitors of the Mdm2-p53 interaction, including NSC 66811, induce p53- and p21-dependent cell cycle arrest and p53-dependent cell death in tumor cell lines.{31196}

Size	1 mg
Shipping	dry ice
CAS Number	6964-62-1
Molecular Formula	C₂₃H₂₀N₂O
SMILES	CC1=NC2=C(O)C(C(NC3=CC=CC=C3)C4=CC=CC=C4)=CC=C2C=C1
Molecular Weight	340,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2907.19
UNSPSC code	12352100

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MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

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