Sucrose octasulfate (potassium s

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Sucrose octasulfate (potassium salt)

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Cat No: 16382

Biochemicals - Small Molecule Inhibitors

Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bi...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2,3,4,6-tetrakis(hydrogen sulfate),1,3,4,6-tetra-O-sulfo-?-D-fructofuranosyl ?-D-glucopyranoside, octapotassium salt

Correlated keywords:

gastroprotective sucralfate gastrointestinal protectants alkalines inhibitors gastric pH thrombin fibroblasts growths factors FGF-2 antitumors 57680-56-5 Agents M 01 sucrosofate potassiums inhibits inhibitions FGF2 FGF 2 two anti-tumors anti tumors salts K KSOS aluminum-sucrose aluminum complex peptic hydrolysis protects protecting esophageal epithelium acids injury binds exosite II catalytic activity surrogate heparin mouse melanoma lungs carcinoma models preventing prevents 2 two FGF2 FGF binding endothelial cells removing removes pre-bound prebound

Product Overview:
Sucrose octasulfate (SOS), a component of the gastrointestinal protectant sucralfate, is an alkaline aluminum−sucrose complex that inhibits peptic hydrolysis and raises gastric pH, protecting esophageal epithelium against acid injury.{26737} It can bind to exosite II of thrombin (KD = ~1.4 µM) and inhibit its catalytic activity (IC50 = 4.5 µM) and, as such, has been used as a surrogate for heparin.{26734} Furthermore, SOS has been shown to inhibit tumor growth in mouse melanoma and lung carcinoma models by preventing fibroblast growth factor 2 (FGF-2) binding to endothelial cells and also by removing any pre-bound FGF-2 from these cells (IC50 = ~2 µg/ml).{26736}

Size	500 mg
Shipping	dry ice
CAS Number	73264-44-5
Molecular Formula	C₁₂H₁₄O₃₅S₈ • 8K
SMILES	O=S(O[C@H]1[C@H](OS(=O)([O-])=O)[C@@H](COS(=O)([O-])=O)O[C@H](O[C@]2(COS(=O)([O-])=O)O[C@H](COS(=O)([O-])=O)[C@@H](OS(=O)([O-])=O)[C@@H]2OS(=O)([O-])=O)[C@@H]1OS(=O)([O-])=O)([O-])=O.[K+].[K+].[K+].[K+].[K+].[K+].[K+].[K+]
Molecular Weight	1287,5
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2930.90
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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