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SR 11302

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    SR 11302
  • SR 11302
Cat No: 16338
Biochemicals - Small Molecule Inhibitors
Cayman

The receptors for retinoids, RARs and RXRs, induce transcriptional activation by binding the specific retinoid response elements, RARE and RXRE.{24737} Alternatively, retinoid receptors interact with and modulate other transcription factors, including ...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (2E,4E,6Z,8E)-3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
Correlated keywords:
  • biochemical nuclear receptor agonist cancer gene regulation inflammation synthetic retinoid AP-1 AP1 inhibit inhibitor activation suppress phorbol ester-induced papilloma formation elucidate signaling pathway
Product Overview:
The receptors for retinoids, RARs and RXRs, induce transcriptional activation by binding the specific retinoid response elements, RARE and RXRE.{24737} Alternatively, retinoid receptors interact with and modulate other transcription factors, including activator protein-1 (AP-1).{24737} SR 11302 is a synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE.{28072} It significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 µM).{28073} SR 11302 is used to elucidate the role of AP-1 in various signaling pathways.{28074,28075}
Size 1 mg
Shipping dry ice
CAS Number 160162-42-5
Molecular Formula C26H32O2
SMILES CC1=C(/C=C/C(C2=CC=C(C)C=C2)=C/C=C/C(C)=C/C(O)=O)C(C)(C)CCC1
Molecular Weight 376,5
Formulation A crystalline solid
Purity ≥95%
Custom Code 2916.39
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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Cross selling for this product : SR 11302 There is one product.

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