BIO-Acetoxime

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BIO-Acetoxime

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Cat No: 16329

Biochemicals - Kinase Inhibitors

BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO (Item No. 13123).{17160,17161} It potently inhibits GSK3α/β (IC50 = 10 nM), with selectivity over Cdk5/p25, Cdk2/A, and Cdk1/B (IC50s = 2.4, 4.3, and 63 µM, respectivel...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-[3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-indol-2-one

Correlated keywords:

667463-85-6 1044661-40-6 1110670-47-7 biochemical inhibitor intracellular signaling antiviral cell biology signal transduction Alzheimer’s research neuroscience GSK3 GSK-3 GSK3? GSK3? acetoxime analog 6-bromoindirubin-3’-oxime inhibit Wnt/?-catenin pathway suppress suppressor cytopathic effect herpes virus reduce viral yield human oral epithelial cells potent selective BIOacetoxime

Product Overview:
BIO-Acetoxime is an analog of the GSK3 inhibitor 6-bromoindirubin-3’-oxime, or BIO (Item No. 13123).{17160,17161} It potently inhibits GSK3α/β (IC50 = 10 nM), with selectivity over Cdk5/p25, Cdk2/A, and Cdk1/B (IC50s = 2.4, 4.3, and 63 µM, respectively).{17160,17161} BIO-Acetoxime has been used to study the role of GSK3 in the Wnt/β-catenin pathway.{27753} It also suppresses the cytopathic effects of herpes viruses and reduces viral yields in human oral epithelial cells.{27754}

Size	1 mg
Shipping	dry ice
CAS Number	740841-15-0
Molecular Formula	C₁₈H₁₂BrN₃O₃
SMILES	CC(O/N=C(/C(N1)=C2C(NC3=C\2C=CC(Br)=C3)=O)C4=C1C=CC=C4)=O
Molecular Weight	398,2
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.49
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.