trans-Urocanic Acid

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trans-Urocanic Acid

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Cat No: 16228

Biochemicals - More Biochemicals

trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine.{26632} It contributes to the acidification of ...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

3-(1H-imidazol-5-yl)-2E-propenoic acid

Correlated keywords:

7699-?36-?7 739340-?22-?8 926068-?43-?1 104-98-3 photoprotective epidermis skin chromophores immunosuppression ultraviolet UV radiation stratum corneum L-histidine ammonia lyase histidine sunscreens DNA damages keratinocytes epidermal immunosuppressive mammals mammalian stratum corneum ammonialyase apoptosis UVB cis isomers regulatory T cells urocanic acids (E)-Urocanic repairs immunology metabolism

Product Overview:
trans-Urocanic acid is a major epidermal chromophore for the immunosuppressive effects of UV radiation that is produced in mammalian stratum corneum by the action of histidine ammonialyase on L-histidine.{26632} It contributes to the acidification of the surface of the stratum corneum, and its function has been proposed as that of an endogenous sunscreen, endowing a low-level of protection (SPF ~ 1.5) against UV-induced DNA damage and excessive keratinocyte apoptosis.{26632} Upon UVB exposure, trans-urocanic acid is converted to the cis isomer, which is known to activate regulatory T cells.{26631}

Size	1 g
Shipping	dry ice
CAS Number	3465-72-3
Molecular Formula	C₆H₆N₂O₂
SMILES	OC(/C=C/C1=CN=CN1)=O
Molecular Weight	138,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.29
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.