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Sphingosine-1-phosphate (d18:1)

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    Sphingosine-<wbr/>1-<wbr/>phosphate (d18:1)
  • Sphingosine-<wbr/>1-<wbr/>phosphate (d18:1)
Cat No: 62570
Biochemicals - Lipids
Cayman
€125.00
Price is excluding VAT and does not include packaging neither shipping

Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase. Like many products of sphingomyelin, it exhibits a wide range of biological activities. Not only does it enhance cell growth,{2486} but it can inhibi...

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Territorial Availability: Available through Bertin Technologies only in Europe
Synonyms:
  • 2S-amino-4E-octadecene-1,3R-diol 1-(dihydrogen phosphate)
Correlated keywords:
  • sphingosines phosphates ceramides apoptosis Sphingosine-1-phosphoric acids cells death kinases sphingomyelin growth calcium D-erythro-Sphingosine-1-phosphate
Product Overview:
Sphingosine-1-phosphate (S1P) is the product of phosphorylation of sphingosine by sphingosine kinase. Like many products of sphingomyelin, it exhibits a wide range of biological activities. Not only does it enhance cell growth,{2486} but it can inhibit the normal apoptotic response to a variety of stimuli.{2904} The ability of PKC to block apoptosis is likely due to the formation of S1P. S1P stimulates MAPK and counteracts the ceramide-induced activation of SAPK and JNK.{2904} It also increases intracellular calcium levels by both the liberation of calcium from internal stores{2750} and through activation of a Gi protein-coupled receptor resulting in the opening of a cell surface calcium channel.{2815}
Size 1 mg
Shipping dry ice
Stability Store at -20 degrees; shelf life 365 days
CAS Number 26993-30-6
Molecular Formula C18H38NO5P
SMILES CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)COP(O)(O)=O
Molecular Weight 379,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2905.59
UNSPSC code 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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