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Benztropine (mesylate)

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    Benztropine (mesylate)
  • Benztropine (mesylate)
Cat No: 16214
Biochemicals - Receptor Pharmacology
Cayman

Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes).{26585} It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • (3-endo)-3-(diphenylmethoxy)-8-methyl-8-azabicyclo[3.2.1]octane, monomethanesulfonate
Correlated keywords:
  • anticholinergic antimuscarinic antagonizes dopamine transporter inhibition sphingomyelinase synthetics atropines diphenhydramines mesylates involuntary tremors dystonias uptake benztropinum cobrentin akitan apo pms cogentinol benzatropinum methanesulfonate MK02 MK-02 NSC169913 tropines benzohydryl ether 3-diphenylmethoxytropane benzotropine benzatropine anti-cholinergic muscarinic Cogentin
Product Overview:
Benztropine is an antagonist of M1 muscarinic acetylcholine receptors (Ki = 0.59 nM in rat brain membranes).{26585} It is selective for M1 receptors over the serotonin transporter (Ki = 5,150 nM), however, it also binds to the dopamine transporter and inhibits dopamine reuptake (Kis = 237 and 130 nM, respectively).{26585,20213,26584} Benztropine also inhibits acid sphingomyelinase by 87% when used at a concentration of 10 mM.{26583} Formulations containing benztropine have been used in the management of Parkinson's disease symptoms such as involuntary tremor and dystonia.
Size 1 g
Shipping dry ice
CAS Number 132-17-2
Molecular Formula C21H25NO • CH3SO3H
SMILES CN1[C@@H]2C[C@@H](OC(C3=CC=CC=C3)C4=CC=CC=C4)C[C@H]1CC2.OS(C)(=O)=O
Molecular Weight 403,5
Formulation A crystalline solid
Purity ≥98%
Custom Code 2922.19
UNSPSC code 12352100

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Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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