Pyrintegrin

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Pyrintegrin

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Cat No: 16179

Biochemicals - More Biochemicals

Human embryonic stem cells (hESC), unlike murine ESC, grow in vitro as large flattened two dimensional colonies.{23249} Dispersing these colonies, using trypsin to dissociate single hESC, results in massive cell death.{23249} Pyrintegrin is a 2,4-disub...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

N-(cyclopropylmethyl)-4-[[4-(3,4-dihydro-6-hydroxy-1(2H)-quinolinyl)-2-pyrimidinyl]amino]-benzenesulfonamide

Correlated keywords:

stems cells signals transductions biology mitogen-activated proteins kinases mitogens activated phosphatidylinositol-3-kinase phosphatidylinositol 3-kinase 3 three PI3K MAPK 2,4-disubstituted pyrimidines 2 4 disubstituted di-substituted di substituted survivals hESC embryonic trypsin-mediated trypsin mediated dissociations integrin-dependent integrin dependents attachments extracellulars matrices matrix matrigel laminin proliferations binding binds activated ? ?1 beta1 .beta.1 beta .beta. 1 one integrin-specific specifics antibody HUTS-21 HUTS 21 phosphorylation growths factors receptors downstream down-stream downs streams enhancers human HUTS21 research

Product Overview:
Human embryonic stem cells (hESC), unlike murine ESC, grow in vitro as large flattened two dimensional colonies.{23249} Dispersing these colonies, using trypsin to dissociate single hESC, results in massive cell death.{23249} Pyrintegrin is a 2,4-disubstituted pyrimidine that, at 2 µM, enhances the survival of hESC more than 30-fold after trypsin-mediated dissociation.{23249} It increases integrin-dependent attachment of hESC to extracellular matrices, including Matrigel™ and laminin, without significantly impacting cell proliferation.{23249} Pyrintegrin increases the binding of the activated β1 integrin-specific antibody HUTS-21 and enhances the phosphorylation of multiple growth factor receptors and their downstream kinases, PI3K and MAPK.{23249}

Size	1 mg
Shipping	dry ice
CAS Number	1228445-38-2
Molecular Formula	C₂₃H₂₅N₅O₃S
SMILES	OC1=CC2=C(C=C1)N(C3=CC=NC(NC4=CC=C(S(NCC5CC5)(=O)=O)C=C4)=N3)CCC2
Molecular Weight	451,5
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2933.59
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.