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Seco Rapamycin (sodium salt)

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    Seco Rapamycin (sodium salt)
  • Seco Rapamycin (sodium salt)
Cat No: 16158
Biochemicals - Small Molecule Inhibitors
Cayman

Rapamycin (Item No. 13346) is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin (Item No. 13346) resulting from ester hydration followed by dehydration.{2...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • [2R-[2?,2(S*),3?,6?[2S*,3E,5E,7E,9S*,11R*,13R*,14R*,15E,7R*,19E,21R*,22(1S*,3R*,4R*)]]]-1-[oxo[tetrahydro-2-hydroxy-6-[14-hydroxy-22-(4-hydroxy-3methoxycyclohexyl)-2,13-dimethoxy-3,9,11,15,17,21-hexamethyl-12,18-dioxo-3,5,7,15,19-docosapentaenyl]-3-methyl-2H-pyran-2-yl]acetyl]-2-piperidinecarboxylic acid, monosodium salt
Correlated keywords:
  • 147438-27-5 intracellular signaling inhibitors cells biology signals inhibits inhibitions degradations degrades products natural macrolides immune systems immunosuppressants activates activations mTORC1 nonenzyme-dependents nonenzymes dependents rapamycins esters hydrations hydrates dehydrations thymocytes proliferations assays kits proliferates ring-opened rings opened cytoplasms homogenates Caco-2 caco2 caco 2 Caco-two cacotwo caco two Caco-II cacoII caco II cells secreted secretes secretions p-glycoproteins pglycoproteins p glycoproteins metabolizes metabolisms metabolized dihydro species mTOR proteasomes mammalian targets of complex complexes 1 I one
Product Overview:
Rapamycin (Item No. 13346) is a natural macrolide immunosuppressant that activates mTORC1. Seco Rapamycin (sodium salt) is a nonenzyme-dependent degradation product of rapamycin (Item No. 13346) resulting from ester hydration followed by dehydration.{26501} It has less than 4% of the potency of rapamycin in a thymocyte proliferation assay.{26501} Rapamycin quickly degrades to two ring-opened products, including seco rapamycin, in the cytoplasm or in homogenates of Caco-2 cells.{26499} Like rapamycin, seco rapamycin is secreted from cells by P-glycoprotein and metabolized to a common dihydro species.{26500} While seco rapamycin poorly activates mTOR, it mimics rapamycin in its ability to inhibit the proteasome.{26502}
Size 1 mg
Shipping dry ice
CAS Number 148554-65-8
Molecular Formula C51H79NO13 • Na
SMILES O[C@@H]1CC[C@@H](C[C@@H](C)/C=C/C([C@H](C)/C=C(C)/[C@@H](O)[C@@H](OC)C([C@H](C)C[C@H](C)/C=C/C=C/C=C([C@@H](OC)C[C@@H]2CC[C@@H](C)[C@](O)(C(C(N3CCCC[C@H]3C(O)=O)=O)=O)O2)\C)=O)=O)C[C@H]1OC.[Na]
Molecular Weight 936,2
Formulation A crystalline solid
Purity ≥85%
Custom Code 2933.49
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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