CH 223191

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CH 223191

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Cat No: 16154

Biochemicals - Small Molecule Inhibitors

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that up-regulates many xenobiotic metabolizing enzymes, particularly in response to planar aromatic hydrocarbons.{26362} CH 223191 is a potent and specific antagonist of AhR...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

1-methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamide

Correlated keywords:

receptors antagonists stems cells immunology genes regulations toxicology environmental CH-223191 AhR aryl hydrocarbons blocks blocking blocked blockages activations TCDD 2,3,7,8-tetrachlorodibenzo-p-dioxin 2 3 7 8 tetrachlorodibenzo dioxin prevents inductions CYP1A1 CYP 1A1 cytochrome P450 P 450 HepG2 cells Hep G2 livers mice suppresses Th17 Th 17 differentiation in vitro in vivo expression homeobox transcription factors embryonic cardiomyocytes

Product Overview:
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that up-regulates many xenobiotic metabolizing enzymes, particularly in response to planar aromatic hydrocarbons.{26362} CH 223191 is a potent and specific antagonist of AhR that blocks activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, IC50 = 0.03 µM).{26363} It prevents the induction of cytochrome P450 1A1 by TCDD in HepG2 cells and in livers of mice.{26363} Through its effects on AhR, CH 223191 suppresses Th17 cell differentiation both in vitro and in vivo and alters the expression of homeobox transcription factors necessary for the differentiation of embryonic stem cells to cardiomyocytes.{26364,26361}

Size	5 mg
Shipping	dry ice
CAS Number	301326-22-7
Molecular Formula	C₁₉H₁₉N₅O
SMILES	CC1=CC=CC=C1/N=N/C2=CC(C)=C(NC(C3=CC=NN3C)=O)C=C2
Molecular Weight	333,4
Formulation	A crystalline solid
Purity	≥95%
Custom Code	2922.19
UNSPSC code	12352100

Technical File

MSDS

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.