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1-(1-Naphthyl)piperazine (hydrochloride)

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    1-<wbr/>(1-Naphthyl)<wbr/>piperazine (hydro<wbr/>chloride)
  • 1-<wbr/>(1-Naphthyl)<wbr/>piperazine (hydro<wbr/>chloride)
Cat No: 16150
Biochemicals - Receptor Pharmacology
Cayman

1-(1-Naphthyl)piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT1 and 5-HT2 in rat cortical membranes with IC50 values of 6 and 1 nM, respectively.{26540} 1-NP also blocks contr...

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Territorial Availability: Available through Bertin Technologies only in France
Synonyms:
  • 1-(1-naphthalenyl)-piperazine, monohydrochloride
Correlated keywords:
  • receptors antagonists neurosciences 57536-86-4 naphthyl piperazine 1NP 1 NP ligands serotonin 5-hydroxytryptamine 5-HT 5 HT five hydroxytryptamine 5-HT1 5-HT2 5HT1 5HT2 HT1 HT2 1 2 one two 5HT rats cortical membranes blocks blocked blockages contractions fundus induced induces tryptamines agonists mimics 1-(m-trifluoromethylphenyl)piperazine trifluoromethylphenyls piperazines TFMPP turnovers serums corticosterones operant behaviors binds humans 5-HT6 5HT6 HT6 6 six affinity
Product Overview:
1-(1-Naphthyl)piperazine (1-NP) is a ligand for serotonin (5-hydroxytryptamine, 5-HT) receptors. It acts as an antagonist for 5-HT at 5-HT1 and 5-HT2 in rat cortical membranes with IC50 values of 6 and 1 nM, respectively.{26540} 1-NP also blocks contraction in the rat fundus induced by either 5-HT or tryptamine (IC50 = 1 nM for both agonists).{26540} 1-NP mimics the 5-HT1 agonist 1-(m-trifluoromethylphenyl)piperazine (TFMPP, Item No. 11205) in decreasing 5-HT receptor turnover and increasing serum corticosterone, suggesting that, in the absence of 5-HT, 1-NP may act as an agonist of the 5-HT1 receptor.{26539} However, in squirrel monkeys, 1-NP acts as a non-selective 5-HT receptor antagonist in altering operant behavior.{26539} 1-NP also binds to the human 5-HT6 receptor with an affinity comparable to that of 5-HT (Kis = 120 and 100 nM, respectively).{26538}
Size 25 mg
Shipping dry ice
CAS Number 104113-71-5
Molecular Formula C14H16N2 • HCl
SMILES C1(C(N2CCNCC2)=CC=C3)=C3C=CC=C1.Cl
Molecular Weight 248,7
Formulation A crystalline solid
Purity ≥98%
Custom Code 2933.59
UNSPSC code 12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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