PD 123319 (trifluoroacetate salt

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PD 123319 (trifluoroacetate salt)

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Cat No: 16099

Biochemicals - Receptor Pharmacology

Angiotensin II is a peptide hormone that regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure. It binds with high affinity to two distinct rece...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

(6S)-1-[[4-(dimethylamino)-3-methylphenyl]methyl]-5-(2,2-diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid, di(2,2,2-trifluoroacetate)

Correlated keywords:

130663-39-7 angiotensin II blood pressures hypertensions atherosclerosis AT1R types 1 receptors AT2R 2 vasoconstriction vasodilation antagonists II PDs 123319 PD123319 PD-123319 selective non-peptides nonpeptides non peptides AT2R hypertensive vascular diseases cardiology atherosclerosis ditrifluoroacetates

Product Overview:
Angiotensin II is a peptide hormone that regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure. It binds with high affinity to two distinct receptors: AT1R (angiotensin type 1 receptor) and AT2R (angiotensin type 2 receptor). AT1R activation facilitates the ‘classical’ effects, including vasoconstriction, cellular growth, and proliferation, whereas AT2R activation offsets AT1R-mediated actions, promoting vasodilatation, apoptosis, and anti-growth effects.{26232} PD 123319 is a selective, nonpeptide AT2R antagonist (IC50 = 5.6 nM vs. 100 nM for AT1R).{26232,26235} It has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models.{26234,26233}

Size	5 mg
Shipping	dry ice
CAS Number	136676-91-0
Molecular Formula	C₃₁H₃₂N₄O₃ • 2CF₃COOH
SMILES	O=C(O)[C@H]1N(C(C(C2=CC=CC=C2)C3=CC=CC=C3)=O)CC4=C(N(CC5=CC=C(N(C)C)C(C)=C5)C=N4)C1.FC(F)(C(O)=O)F.FC(F)(C(O)=O)F
Molecular Weight	736,7
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2933.49
UNSPSC code	12352100

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