Clomiphene (citrate)

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Cat No: 16087

Biochemicals - Receptor Pharmacology

Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol.{23588,23594} It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively).{23592} Clomiphene enhances the release...

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Territorial Availability: Available through Bertin Technologies only in France

Synonyms:

2-[4-(2-chloro-1,2-diphenylethenyl)phenoxy]-N,N-diethyl-ethanamine, 2-hydroxy-1,2,3-propanetricarboxylate

Correlated keywords:

911-45-5 receptors antagonist steroids cancers reproductive biology estrogen modulators SERMs impairs ERs estrogen receptors 17?-estradiol 17beta-estradiol 17.beta.-estradiol 17b-estradiol esteradiols ER? Era ERalpha ER.alpha. ER? ERb ERbeta ER.beta. gonadotropin hormones ovulation ovulates chloramiphene clomhexal clomid clomifeno clomivid clomphid clostilbegit clostibegyt dyneric fertivet fertyl fertyl genozym ikaclomin ikaclomine klomen MRLs 41 MRL41 MRL-41 Mer-41 Mers Mer41 NSCs 35770 NSC35770 NSC-35770 omifin pergotime racemic serophene siphene Clomifene 14813 and clomiphene B

Product Overview:
Clomiphene is a selective estrogen receptor modulator that impairs the activation of estrogen receptors (ERs) by 17β-estradiol.{23588,23594} It potently binds both ERα and ERβ (Ki = 0.9 and 1.2 nM, respectively).{23592} Clomiphene enhances the release of gonadotropin-releasing hormone, stimulating the release of follicle-stimulating hormone and luteinizing hormone, culminating in ovulation.{23591,23588}

Size	1 g
Shipping	dry ice
CAS Number	50-41-9
Molecular Formula	C₂₆H₂₈ClNO • C₆H₈O₇
SMILES	Cl/C(C1=CC=CC=C1)=C(C2=CC=CC=C2)\C3=CC=C(OCCN(CC)CC)C=C3.OC(CC(O)=O)(C(O)=O)CC(O)=O
Molecular Weight	598,1
Formulation	A crystalline solid
Purity	≥98%
Custom Code	2903.99
UNSPSC code	12352100

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Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

Accreditations
ISO/IEC 17025:2005
ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.